Homocysteine, Vitamins, and Cardiovascular Disease

Homocysteine, vitamins, and cardiovascular disease.

The significance of any association between cardiovascular disease and circulating homocysteine concentrations is attracting considerable attention. The normal activities of the transsulfuration and remethylation pathways maintain intracellular homocysteine levels within a narrow range, and the controlled release of homocysteine into blood results in blood measurements that provide an accurate ...

Homocysteine and vitamins in cardiovascular disease.

On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired enzyme function as a result of genetic mutation or deficiency of the essential B vitamins folic acid, B12, and B6 can lead to hyperhomocysteinemia. Oxidized forms of homocysteine account for 98-99% of total plasma ...

Homocysteine, B-vitamins, and the risk of cardiovascular disease.

Featured Article: Clarke R, Daly L, Robinson K, Naughton E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149 –55. Our report, published in the New England Journal of Medicine in 1991, demonstrated that hyperhomocysteinemia was present in about one-third of cases with early-onset coronary heart disease, cerebral vas...

Homocysteine, B vitamins, and risk of cardiovascular disease.

Vitamins and cardiovascular disease.

CVD is a major cause of mortality and morbidity in the Western world. In recent years its importance has expanded internationally and it is believed that by 2020 it will be the biggest cause of mortality in the world, emphasising the importance to prevent or minimise this increase. A beneficial role for vitamins in CVD has long been explored but the data are still inconsistent. While being supp...